EC number:2.7.7.79
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.79 |
|---|---|
| Description: | tRNA(His) guanylyltransferase. |
| Alternative Name: |
Histidine tRNA guanylyltransferase. |
| Cath: | 3.30.70.3000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.79 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.79 |
| KEGG Enzyme Link: | KEGG2.7.7.79 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.79 |
| ExPASy Enzyme Link: | ExPASy2.7.7.79 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.79 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.79 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.79 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.79 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.79 |
| RHEA:54564 | 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[*:9]-[P;H0;+0:10](=[*:11])(-[*:12])-[OH;+0:13]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:10](-[*:9])(=[*:11])-[*:12].[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[OH;+0:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. | Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublié S | 2010 Nov 23 | 21059936 |
| Plant mitochondria use two pathways for the biogenesis of tRNAHis. | Placido A, Sieber F, Gobert A, Gallerani R, Giegé P, Maréchal-Drouard L | 2010 Nov | 20660484 |
| Identification of critical residues for G-1 addition and substrate recognition by tRNA(His) guanylyltransferase. | Jackman JE, Phizicky EM | 2008 Apr 22 | 18366186 |
| Histidine tRNA guanylyltransferase from Saccharomyces cerevisiae. II. Catalytic mechanism. | Jahn D, Pande S | 1991 Dec 5 | 1660462 |
| Histidine tRNA guanylyltransferase from Saccharomyces cerevisiae. I. Purification and physical properties. | Pande S, Jahn D, Söll D | 1991 Dec 5 | 1660461 |
| tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis. | Gu W, Jackman JE, Lohan AJ, Gray MW, Phizicky EM | 2003 Dec 1 | 14633974 |
| Saccharomyces cerevisiae Thg1 uses 5'-pyrophosphate removal to control addition of nucleotides to tRNA(His.). | Smith BA, Jackman JE | 2014 Mar 4 | 24548272 |
| Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily. | Jackman JE, Gott JM, Gray MW | 2012 May | 22456265 |