EC number:2.7.7.84
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.84 |
|---|---|
| Description: | 2'-5' oligoadenylate synthase. |
| Cath: | 1.10.1410.20; 3.30.460.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.84 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.84 |
| KEGG Enzyme Link: | KEGG2.7.7.84 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.84 |
| ExPASy Enzyme Link: | ExPASy2.7.7.84 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.84 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.84 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.84 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.84 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.84 |
| RHEA:34407 | 3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate |
| RULE(radius=1) | ([*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]).[*:9]-[OH;+0:10].[*:11]=[P;H0;+0:12](-[*:13])(-[*:14])-[O;H0;+0:15]-[*:16]>>[*:1]-[OH;+0:2].[*:16]-[OH;+0:15].([*:11]=[P;H0;+0:12](-[*:13])(-[*:14])-[O;H0;+0:8]-[*:7].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:10]-[*:9]) |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material. | Martin EM, Birdsall NJ, Brown RE, Kerr IM | 1979 Apr 2 | 456356 |
| pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. | Kerr IM, Brown RE | 1978 Jan | 272640 |
| Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. | Donovan J, Dufner M, Korennykh A | 2013 Jan 29 | 23319625 |
| The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation. | Hovanessian AG, Justesen J | 2007 Jun-Jul | 17408844 |
| Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase. | Hartmann R, Justesen J, Sarkar SN, Sen GC, Yee VC | 2003 Nov | 14636576 |
| Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. | Eskildsen S, Justesen J, Schierup MH, Hartmann R | 2003 Jun 15 | 12799444 |