EC number:2.7.7.85

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.7 Nucleotidyltransferases
ID:2.7.7.85
Description:Diadenylate cyclase.
Alternative Name: Cyclic-di-AMP synthase.
Cath: 1.10.150.20; 1.10.287.770; 1.20.1260.110; 3.40.1700.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.7.85
BRENDA Enzyme Link: BRENDA 2.7.7.85
KEGG Enzyme Link: KEGG2.7.7.85
BioCyc Enzyme Link: BioCyc 2.7.7.85
ExPASy Enzyme Link: ExPASy2.7.7.85
EC2PDB Enzyme Link: EC2PDB 2.7.7.85
ExplorEnz Enzyme Link: ExplorEnz 2.7.7.85
PRIAM enzyme-specific profiles Link: PRIAM 2.7.7.85
IntEnz Enzyme Link: IntEnz 2.7.7.85
MEDLINE Enzyme Link: MEDLINE 2.7.7.85

EC number:2.7.7.85

MSA:

2.7.7.85;
Phylogenetic Tree:

2.7.7.85;
Uniprot:
M-CSA:
RHEA:35655 2 ATP = c-di-AMP + 2 diphosphate
RULE(radius=1) ([*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]).([*:9]-[OH;+0:10].[*:11]=[P;H0;+0:12](-[*:13])(-[*:14])-[O;H0;+0:15]-[*:16])>>([*:9]-[O;H0;+0:10]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:11]=[P;H0;+0:12](-[*:13])(-[*:14])-[O;H0;+0:8]-[*:7]).[*:1]-[OH;+0:2].[*:16]-[OH;+0:15]
Reaction
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References

TitleAuthorsDatePubMed ID
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.Woodward JJ, Iavarone AT, Portnoy DA2010 Jun 2520508090
Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates.Witte G, Hartung S, Büttner K, Hopfner KP2008 Apr 2518439896