EC number:2.7.7.97
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.97 |
|---|---|
| Description: | 3-hydroxy-4-methylanthranilate adenylyltransferase. |
| Alternative Name: |
Actinomycin synthase I. 4-MHA-activating enzyme. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.97 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.97 |
| KEGG Enzyme Link: | KEGG2.7.7.97 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.97 |
| ExPASy Enzyme Link: | ExPASy2.7.7.97 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.97 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.97 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.97 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.97 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.97 |
| RHEA:24980 | 3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-adenylate + diphosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[H+;H0:9]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. | Giessen TW, Kraas FI, Marahiel MA | 2011 Jun 28 | 21612226 |
| Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces. | Pfennig F, Schauwecker F, Keller U | 1999 Apr 30 | 10212227 |