EC number:2.7.8.13
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.8 Transferases for other substituted phosphate groups |
| ID: | 2.7.8.13 | ||||||
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| Description: | Phospho-N-acetylmuramoyl-pentapeptide-transferase. | ||||||
| Alternative Name: |
UDP-MurNAc-pentapeptide phosphotransferase. UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase. UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate Phosphoacetylmuramoylpentapeptidetransferase. Phosphoacetylmuramoylpentapeptide translocase. Phospho-NAc-muramoyl-pentapeptide translocase (UMP). Phospho-N-acetylmuramoyl pentapeptide translocase. Phospho-MurNAc-pentapeptide transferase. MraY transferase. | ||||||
| Prosite: | PDOC01046; | ||||||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.8.13 |
| BRENDA Enzyme Link: | BRENDA 2.7.8.13 |
| KEGG Enzyme Link: | KEGG2.7.8.13 |
| BioCyc Enzyme Link: | BioCyc 2.7.8.13 |
| ExPASy Enzyme Link: | ExPASy2.7.8.13 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.8.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.8.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.8.13 |
| IntEnz Enzyme Link: | IntEnz 2.7.8.13 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.8.13 |
| RHEA:21920 | di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UMP |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Recent advances in the formation of the bacterial peptidoglycan monomer unit. | van Heijenoort J | 2001 Oct | 11699883 |
| On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate). | Struve WG, Sinha RK, Neuhaus FC | 1966 Jan | 5938956 |
| The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase. | Heydanek MG Jr, Neuhaus FC | 1969 Apr | 5805290 |
| Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol. | Higashi Y, Strominger JL, Sweeley CC | 1967 Jun | 5231417 |
| Purification and characterization of the bacterial MraY translocase catalyzing the first membrane step of peptidoglycan biosynthesis. | Bouhss A, Crouvoisier M, Blanot D, Mengin-Lecreulx D | 2004 Jul 16 | 15131133 |