EC number:2.7.8.17
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.8 Transferases for other substituted phosphate groups |
| ID: | 2.7.8.17 |
|---|---|
| Description: | N-acetylglucosaminephosphotransferase. |
| Alternative Name: |
N-acetylglucosaminylphosphotransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.8.17 |
| BRENDA Enzyme Link: | BRENDA 2.7.8.17 |
| KEGG Enzyme Link: | KEGG2.7.8.17 |
| BioCyc Enzyme Link: | BioCyc 2.7.8.17 |
| ExPASy Enzyme Link: | ExPASy2.7.8.17 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.8.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.8.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.8.17 |
| IntEnz Enzyme Link: | IntEnz 2.7.8.17 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.8.17 |
| RHEA:13581 | N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes. | Reitman ML, Kornfeld S | 1981 Dec 10 | 6457829 |
| UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes. | Reitman ML, Kornfeld S | 1981 May 10 | 6452459 |
| UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme. | Waheed A, Hasilik A, von Figura K | 1982 Oct 25 | 6288715 |
| Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes. | Waheed A, Pohlmann R, Hasilik A, von Figura K | 1981 May 10 | 6260788 |
| Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. | Qian Y, Lee I, Lee WS, Qian M, Kudo M, Canfield WM, Lobel P, Kornfeld S | 2010 Jan 29 | 19955174 |