EC Tree |
2. Transferases |
2.8 Transferring sulfur-containing groups |
2.8.1 Sulfurtransferases |
ID: | 2.8.1.6 |
---|---|
Description: | Biotin synthase. |
Cath: | 3.20.20.70; |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 2.8.1.6 |
BRENDA Enzyme Link: | BRENDA 2.8.1.6 |
KEGG Enzyme Link: | KEGG2.8.1.6 |
BioCyc Enzyme Link: | BioCyc 2.8.1.6 |
ExPASy Enzyme Link: | ExPASy2.8.1.6 |
EC2PDB Enzyme Link: | EC2PDB 2.8.1.6 |
ExplorEnz Enzyme Link: | ExplorEnz 2.8.1.6 |
PRIAM enzyme-specific profiles Link: | PRIAM 2.8.1.6 |
IntEnz Enzyme Link: | IntEnz 2.8.1.6 |
MEDLINE Enzyme Link: | MEDLINE 2.8.1.6 |
RHEA:22060 | [sulfur carrier]-SH + dethiobiotin + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] |
RULE(radius=1) | [*;H0;+0:1]-[SH;+0:2].[*:3]-[CH2;+0:4]-[*:5]-[*:6]-[CH3;+0:7].[*:8]-[CH2;+0:9]-[S+;H0:10](-[*:11])-[*:12].[*:13]-[Fe;H0;+0:14]-[*:15].[*:16]-[Fe;H0;+0:17]-[*:18]>>[*;H0;+0:1].[*:8]-[CH3;+0:9].[*:3]-[CH;+0:4]1-[*:5]-[*:6]-[CH2;+0:7]-[S;H0;+0:2]-1.[*:13]-[Fe+;H0:14]-[*:15].[*:16]-[Fe+;H0:17]-[*:18].[*:11]-[S;H0;+0:10]-[*:12] |
Reaction | ![]() |
Core-to-Core | |
Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase. | Zhang S, Sanyal I, Bulboaca GH, Rich A, Flint DH | 1994 Feb 15 | 8117110 |
Transcriptional regulation and gene arrangement of Escherichia coli, Citrobacter freundii and Salmonella typhimurium biotin operons. | Shiuan D, Campbell A | 1988 Jul 30 | 2971595 |
Biotin synthase mechanism: an overview. | Lotierzo M, Tse Sum Bui B, Florentin D, Escalettes F, Marquet A | 2005 Aug | 16042606 |
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. | Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL | 2004 Jan 2 | 14704425 |