Enzyme

Download
EC Tree
     2. Transferases
        2.8 Transferring sulfur-containing groups
            2.8.1 Sulfurtransferases
ID:2.8.1.6
Description:Biotin synthase.
Cath: 3.20.20.70;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.8.1.6
BRENDA Enzyme Link: BRENDA 2.8.1.6
KEGG Enzyme Link: KEGG2.8.1.6
BioCyc Enzyme Link: BioCyc 2.8.1.6
ExPASy Enzyme Link: ExPASy2.8.1.6
EC2PDB Enzyme Link: EC2PDB 2.8.1.6
ExplorEnz Enzyme Link: ExplorEnz 2.8.1.6
PRIAM enzyme-specific profiles Link: PRIAM 2.8.1.6
IntEnz Enzyme Link: IntEnz 2.8.1.6
MEDLINE Enzyme Link: MEDLINE 2.8.1.6
MSA:

2.8.1.6;

Phylogenetic Tree:

2.8.1.6;

Uniprot:
M-CSA:
RHEA:22060 [sulfur carrier]-SH + dethiobiotin + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]
RULE(radius=1) [*;H0;+0:1]-[SH;+0:2].[*:3]-[CH2;+0:4]-[*:5]-[*:6]-[CH3;+0:7].[*:8]-[CH2;+0:9]-[S+;H0:10](-[*:11])-[*:12].[*:13]-[Fe;H0;+0:14]-[*:15].[*:16]-[Fe;H0;+0:17]-[*:18]>>[*;H0;+0:1].[*:8]-[CH3;+0:9].[*:3]-[CH;+0:4]1-[*:5]-[*:6]-[CH2;+0:7]-[S;H0;+0:2]-1.[*:13]-[Fe+;H0:14]-[*:15].[*:16]-[Fe+;H0:17]-[*:18].[*:11]-[S;H0;+0:10]-[*:12]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase.Zhang S, Sanyal I, Bulboaca GH, Rich A, Flint DH1994 Feb 158117110
Transcriptional regulation and gene arrangement of Escherichia coli, Citrobacter freundii and Salmonella typhimurium biotin operons.Shiuan D, Campbell A1988 Jul 302971595
Biotin synthase mechanism: an overview.Lotierzo M, Tse Sum Bui B, Florentin D, Escalettes F, Marquet A2005 Aug16042606
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme.Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL2004 Jan 214704425