EC number:2.8.2.8
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.8 |
|---|---|
| Description: | [Heparan sulfate]-glucosamine N-sulfotransferase. |
| Alternative Name: |
PAPS:N-desulfoheparin sulfotransferase. PAPS:DSH sulfotransferase. N-HSST. N-heparan sulfate sulfotransferase. N-desulfoheparin sulfotransferase. Heparitin sulfotransferase. Heparin N-sulfotransferase. Heparan sulfate sulfotransferase. Heparan sulfate N-sulfotransferase. Heparan sulfate N-deacetylase/N-sulfotransferase. Heparan sulfate 2-N-sulfotransferase. Glucosaminyl N-deacetylase/N-sulfotransferase. Desulfoheparin sulfotransferase. 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase. 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase. 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase. |
| Cath: | 3.40.50.300; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.8 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.8 |
| KEGG Enzyme Link: | KEGG2.8.2.8 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.8 |
| ExPASy Enzyme Link: | ExPASy2.8.2.8 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.8 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.8 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.8 |
| RHEA:21980 | 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[NH2;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[NH;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional analysis of conserved cysteines in heparan sulfate N-deacetylase-N-sulfotransferases. | Wei Z, Swiedler SJ | 1999 Jan 22 | 9890952 |
| 3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction. | Eisenman RA, Balasubramanian AS, Marx W | 1967 Mar | 4964017 |
| The enzymatic sulphation of heparan sulphate by hen's uterus. | Johnson AH, Baker JR | 1973 Sep 14 | 4270798 |