EC number:3.1.2.27

Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.2 Thioester hydrolases
ID:3.1.2.27
Description:Choloyl-CoA hydrolase.
Alternative Name: PTE-2.
Peroxisomal acyl-CoA thioesterase 2.
Choloyl-coenzyme A thioesterase.
Chenodeoxycholoyl-coenzyme A thioesterase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.2.27
BRENDA Enzyme Link: BRENDA 3.1.2.27
KEGG Enzyme Link: KEGG3.1.2.27
BioCyc Enzyme Link: BioCyc 3.1.2.27
ExPASy Enzyme Link: ExPASy3.1.2.27
EC2PDB Enzyme Link: EC2PDB 3.1.2.27
ExplorEnz Enzyme Link: ExplorEnz 3.1.2.27
PRIAM enzyme-specific profiles Link: PRIAM 3.1.2.27
IntEnz Enzyme Link: IntEnz 3.1.2.27
MEDLINE Enzyme Link: MEDLINE 3.1.2.27

EC number:3.1.2.27

MSA:

3.1.2.27;
Phylogenetic Tree:

3.1.2.27;
Uniprot:
M-CSA:
RHEA:31511 chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase.Ye HQ, Mallonee DH, Wells JE, Björkhem I, Hylemon PB1999 Jan9869646
The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.O'Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE2003 Sep 512810727
RHEA:16305 (3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase.DEKKER EE, SCHLESINGER MJ, COON MJ1958 Aug13563516
RHEA:14541 choloyl-CoA + H2O = cholate + CoA + H(+)
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase.Ye HQ, Mallonee DH, Wells JE, Björkhem I, Hylemon PB1999 Jan9869646
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.Falany CN, Johnson MR, Barnes S, Diasio RB1994 Jul 298034703
The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.O'Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE2003 Sep 512810727
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.Hunt MC, Solaas K, Kase BF, Alexson SE2002 Jan 1111673457
Demonstration of dimethylnonanoyl-CoA thioesterase activity in rat liver peroxisomes followed by purification and molecular cloning of the thioesterase involved.Ofman R, el Mrabet L, Dacremont G, Spijer D, Wanders RJ2002 Jan 1811785945