EC number:3.1.4.37

Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.4 Phosphoric-diester hydrolases
ID:3.1.4.37
Description:2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Alternative Name: Cyclic-CMP phosphodiesterase.
Cath: 3.90.1740.10; 3.40.220.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.4.37
BRENDA Enzyme Link: BRENDA 3.1.4.37
KEGG Enzyme Link: KEGG3.1.4.37
BioCyc Enzyme Link: BioCyc 3.1.4.37
ExPASy Enzyme Link: ExPASy3.1.4.37
EC2PDB Enzyme Link: EC2PDB 3.1.4.37
ExplorEnz Enzyme Link: ExplorEnz 3.1.4.37
PRIAM enzyme-specific profiles Link: PRIAM 3.1.4.37
IntEnz Enzyme Link: IntEnz 3.1.4.37
MEDLINE Enzyme Link: MEDLINE 3.1.4.37

EC number:3.1.4.37

MSA:

3.1.4.37;
Phylogenetic Tree:

3.1.4.37;
Uniprot:
M-CSA:
RHEA:14489 a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)
RULE(radius=1) [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>([*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7])
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.Kurihara T, Nishizawa Y, Takahashi Y, Odani S1981 Apr 16272743
RHEA:37191 2',3'-cyclic AMP + H2O = adenosine 2'-phosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>([*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7])
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities.Yakunin AF, Proudfoot M, Kuznetsova E, Savchenko A, Brown G, Arrowsmith CH, Edwards AM2004 Aug 2715210699
RHEA:37211 2',3'-cyclic GMP + H2O = guanosine 2'-monophosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>([*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7])
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
tRNA splicing in yeast and wheat germ. A cyclic phosphodiesterase implicated in the metabolism of ADP-ribose 1",2"-cyclic phosphate.Culver GM, Consaul SA, Tycowski KT, Filipowicz W, Phizicky EM1994 Oct 77929175
RHEA:37239 2',3'-cyclic UMP + H2O = H(+) + uridine 2'-phosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>([*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7])
Reaction
Core-to-Core More
RHEA:41956 2',3'-cyclic CMP + H2O = cytidine 2'-phosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>([*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7])
Reaction
Core-to-Core More