EC number:3.2.1.183
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.2 Glycosylases |
| 3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds |
| ID: | 3.2.1.183 |
|---|---|
| Description: | UDP-N-acetylglucosamine 2-epimerase (hydrolyzing). |
| Alternative Name: |
UDP-N-acetylglucosamine 2-epimerase. |
| Cath: | 3.30.420.40; 3.40.50.20; 3.40.50.200; 3.40.50.2000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.2.1.183 |
| BRENDA Enzyme Link: | BRENDA 3.2.1.183 |
| KEGG Enzyme Link: | KEGG3.2.1.183 |
| BioCyc Enzyme Link: | BioCyc 3.2.1.183 |
| ExPASy Enzyme Link: | ExPASy3.2.1.183 |
| EC2PDB Enzyme Link: | EC2PDB 3.2.1.183 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.2.1.183 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.2.1.183 |
| IntEnz Enzyme Link: | IntEnz 3.2.1.183 |
| MEDLINE Enzyme Link: | MEDLINE 3.2.1.183 |
EC number:3.2.1.183
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:30683 | H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[O;H0;+0:5]-[CH;+0:6](-[*:7])-[*:8].[OH2;+0:9]>>([*:7]-[CH;+0:6](-[*:8])-[OH;+0:9].[*:4]-[CH;+0:3]=[O;H0;+0:5]).[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase. | Murkin AS, Chou WK, Wakarchuk WW, Tanner ME | 2004 Nov 9 | 15518580 |
| UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells. | Blume A, Ghaderi D, Liebich V, Hinderlich S, Donner P, Reutter W, Lucka L | 2004 Jun | 15135418 |
| Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-N-acetylglucosamine 2-epimerase. | Chou WK, Hinderlich S, Reutter W, Tanner ME | 2003 Mar 5 | 12603133 |
| A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. | Hinderlich S, Stäsche R, Zeitler R, Reutter W | 1997 Sep 26 | 9305887 |