EC number:3.2.1.207
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.2 Glycosylases |
| 3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds |
| ID: | 3.2.1.207 |
|---|---|
| Description: | Mannosyl-oligosaccharide alpha-1,3-glucosidase. |
| Alternative Name: |
Trimming glucosidase II. ER glucosidase II. Alpha-glucosidase II. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.2.1.207 |
| BRENDA Enzyme Link: | BRENDA 3.2.1.207 |
| KEGG Enzyme Link: | KEGG3.2.1.207 |
| BioCyc Enzyme Link: | BioCyc 3.2.1.207 |
| ExPASy Enzyme Link: | ExPASy3.2.1.207 |
| EC2PDB Enzyme Link: | EC2PDB 3.2.1.207 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.2.1.207 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.2.1.207 |
| IntEnz Enzyme Link: | IntEnz 3.2.1.207 |
| MEDLINE Enzyme Link: | MEDLINE 3.2.1.207 |
EC number:3.2.1.207
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. | Trombetta ES, Simons JF, Helenius A | 1996 Nov 1 | 8910335 |
| Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction. | Mora-Montes HM, Bates S, Netea MG, Díaz-Jiménez DF, López-Romero E, Zinker S, Ponce-Noyola P, Kullberg BJ, Brown AJ, Odds FC, Flores-Carreón A, Gow NA | 2007 Dec | 17933909 |
| Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. | Wilkinson BM, Purswani J, Stirling CJ | 2006 Mar 10 | 16373354 |
| Two isoforms of trimming glucosidase II exist in mammalian tissues and cell lines but not in yeast and insect cells. | Ziak M, Meier M, Etter KS, Roth J | 2001 Jan 12 | 11162524 |
| RHEA:55996 | H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[OH2;+0:6]>>[*:4]-[CH;+0:3](-[*:5])-[OH;+0:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. | Trombetta ES, Simons JF, Helenius A | 1996 Nov 1 | 8910335 |
| Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction. | Mora-Montes HM, Bates S, Netea MG, Díaz-Jiménez DF, López-Romero E, Zinker S, Ponce-Noyola P, Kullberg BJ, Brown AJ, Odds FC, Flores-Carreón A, Gow NA | 2007 Dec | 17933909 |
| Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. | Wilkinson BM, Purswani J, Stirling CJ | 2006 Mar 10 | 16373354 |
| Two isoforms of trimming glucosidase II exist in mammalian tissues and cell lines but not in yeast and insect cells. | Ziak M, Meier M, Etter KS, Roth J | 2001 Jan 12 | 11162524 |