EC number:3.5.2.17
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.2 In cyclic amides |
| ID: | 3.5.2.17 |
|---|---|
| Description: | Hydroxyisourate hydrolase. |
| Alternative Name: |
HIUHase. 5-hydroxyisourate hydrolase. |
| Cath: | 1.10.3330.10; 3.30.9.30; 3.50.50.60; 2.60.40.180; 3.10.270.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.2.17 |
| BRENDA Enzyme Link: | BRENDA 3.5.2.17 |
| KEGG Enzyme Link: | KEGG3.5.2.17 |
| BioCyc Enzyme Link: | BioCyc 3.5.2.17 |
| ExPASy Enzyme Link: | ExPASy3.5.2.17 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.2.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.2.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.2.17 |
| IntEnz Enzyme Link: | IntEnz 3.5.2.17 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.2.17 |
| RHEA:23736 | 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) |
| RULE(radius=1) | [*:1]=[C;H0;+0:2]1-[*:3]-[C;H0;+0:4](-[NH;+0:5]-[*:6])=[N;H0;+0:7]-[*:8]-[NH;+0:9]-1.[OH2;+0:10]>>[*:1]=[C;H0;+0:2](-[OH;+0:10])-[*:3]-[C;H0;+0:4](=[N;H0;+0:5]-[*:6])-[NH;+0:7]-[*:8]-[NH2;+0:9] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter. | Zanotti G, Cendron L, Ramazzina I, Folli C, Percudani R, Berni R | 2006 Oct 13 | 16952372 |
| The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase. | Hennebry SC, Law RH, Richardson SJ, Buckle AM, Whisstock JC | 2006 Jun 23 | 16787778 |