EC number:3.5.4.10
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.4 In cyclic amidines |
| ID: | 3.5.4.10 |
|---|---|
| Description: | IMP cyclohydrolase. |
| Alternative Name: |
Inosinicase. IMP synthetase. |
| Cath: | 1.10.287.440; 3.60.20.20; 3.40.140.20; 3.40.50.1380; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.4.10 |
| BRENDA Enzyme Link: | BRENDA 3.5.4.10 |
| KEGG Enzyme Link: | KEGG3.5.4.10 |
| BioCyc Enzyme Link: | BioCyc 3.5.4.10 |
| ExPASy Enzyme Link: | ExPASy3.5.4.10 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.4.10 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.4.10 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.4.10 |
| IntEnz Enzyme Link: | IntEnz 3.5.4.10 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.4.10 |
| RHEA:18445 | H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide |
| RULE(radius=1) | [*:1]=[c;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[cH;+0:6]:[nH;+0:7]:1.[OH2;+0:8]>>[*:1]=[C;H0;+0:2](-[NH2;+0:7])-[*:3]:[*:4]-[NH;+0:5]-[CH;+0:6]=[O;H0;+0:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. | Le Nours J, Bulloch EM, Zhang Z, Greenwood DR, Middleditch MJ, Dickson JM, Baker EN | 2011 Nov 25 | 21956117 |
| Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. | Vergis JM, Beardsley GP | 2004 Feb 10 | 14756554 |
| Biosynthesis of the purines. XVIII. 5-Amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase and inosinicase. | FLAKS JG, ERWIN MJ, BUCHANAN JM | 1957 Dec | 13502325 |