EC number:3.5.4.19
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.4 In cyclic amidines |
| ID: | 3.5.4.19 |
|---|---|
| Description: | Phosphoribosyl-AMP cyclohydrolase. |
| Cath: | 1.10.287.10; 1.10.287.1080; 1.20.5.130; 1.20.5.1300; 4.10.80.70; 3.40.50.1980; 3.10.20.400; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.4.19 |
| BRENDA Enzyme Link: | BRENDA 3.5.4.19 |
| KEGG Enzyme Link: | KEGG3.5.4.19 |
| BioCyc Enzyme Link: | BioCyc 3.5.4.19 |
| ExPASy Enzyme Link: | ExPASy3.5.4.19 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.4.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.4.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.4.19 |
| IntEnz Enzyme Link: | IntEnz 3.5.4.19 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.4.19 |
| RHEA:20049 | 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide |
| RULE(radius=1) | [*:1]-[n;H0;+0:2]1:[cH;+0:3]:[n;H0;+0:4]:[*:5]:[*:6]:[c;H0;+0:7]:1=[NH;+0:8].[OH2;+0:9]>>[*:1]-[NH;+0:2]-[CH;+0:3]=[N;H0;+0:4]-[*:5]:[*:6]-[C;H0;+0:7](-[NH2;+0:8])=[O;H0;+0:9] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| N1-(5'-phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase: purification and characterization of a unique metalloenzyme. | D'Ordine RL, Klem TJ, Davisson VJ | 1999 Feb 2 | 9931020 |
| Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI. | Sivaraman J, Myers RS, Boju L, Sulea T, Cygler M, Jo Davisson V, Schrag JD | 2005 Aug 2 | 16042384 |