EC number:3.5.4.36
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.4 In cyclic amidines |
| ID: | 3.5.4.36 |
|---|---|
| Description: | mRNA(cytosine(6666)) deaminase. |
| Alternative Name: |
Apolipoprotein B mRNA editing enzyme. |
| Cath: | 3.40.140.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.4.36 |
| BRENDA Enzyme Link: | BRENDA 3.5.4.36 |
| KEGG Enzyme Link: | KEGG3.5.4.36 |
| BioCyc Enzyme Link: | BioCyc 3.5.4.36 |
| ExPASy Enzyme Link: | ExPASy3.5.4.36 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.4.36 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.4.36 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.4.36 |
| IntEnz Enzyme Link: | IntEnz 3.5.4.36 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.4.36 |
| RHEA:21772 | cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA |
| RULE(radius=1) | [*:1]:[c;H0;+0:2](-[NH2;+0:3]):[n;H0;+0:4]:[*:5].[H+;H0:6].[OH2;+0:7]>>[*:1]:[c;H0;+0:2](=[O;H0;+0:7]):[nH;+0:4]:[*:5].[NH3;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Apolipoprotein B mRNA editing in vitro is a zinc-dependent process. | Barnes C, Smith HC | 1993 Dec 30 | 8280158 |
| Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed. | Yamanaka S, Poksay KS, Balestra ME, Zeng GQ, Innerarity TL | 1994 Aug 26 | 8063816 |
| The APOBEC-2 crystal structure and functional implications for the deaminase AID. | Prochnow C, Bransteitter R, Klein MG, Goodman MF, Chen XS | 2007 Jan 25 | 17187054 |
| Optimization of apolipoprotein B mRNA editing by APOBEC1 apoenzyme and the role of its auxiliary factor, ACF. | Chester A, Weinreb V, Carter CW Jr, Navaratnam N | 2004 Sep | 15273326 |
| The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. | Chester A, Somasekaram A, Tzimina M, Jarmuz A, Gisbourne J, O'Keefe R, Scott J, Navaratnam N | 2003 Aug 1 | 12881431 |
| C-->U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica. | Fujino T, Navaratnam N, Jarmuz A, von Haeseler A, Scott J | 1999 Jul 1 | 10373583 |