EC number:3.6.1.60
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.60 |
|---|---|
| Description: | Diadenosine hexaphosphate hydrolase (AMP-forming). |
| Cath: | 3.90.79.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.60 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.60 |
| KEGG Enzyme Link: | KEGG3.6.1.60 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.60 |
| ExPASy Enzyme Link: | ExPASy3.6.1.60 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.60 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.60 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.60 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.60 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.60 |
| RHEA:32051 | H2O + P(1),P(5)-bis(5'-adenosyl)pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. | Hua LV, Hidaka K, Pesesse X, Barnes LD, Shears SB | 2003 Jul 1 | 12689335 |
| Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. | Leslie NR, McLennan AG, Safrany ST | 2002 Jul 16 | 12121577 |
| The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. | Safrany ST, Ingram SW, Cartwright JL, Falck JR, McLennan AG, Barnes LD, Shears SB | 1999 Jul 30 | 10419486 |
| RHEA:32047 | H2O + P(1),P(6)-bis(5'-adenosyl)hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. | Hua LV, Hidaka K, Pesesse X, Barnes LD, Shears SB | 2003 Jul 1 | 12689335 |
| Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. | Leslie NR, McLennan AG, Safrany ST | 2002 Jul 16 | 12121577 |
| The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. | Safrany ST, Ingram SW, Cartwright JL, Falck JR, McLennan AG, Barnes LD, Shears SB | 1999 Jul 30 | 10419486 |