EC number:4.1.2.n2
| ID: | 4.1.2.n2 |
|---|---|
| Description: | 2-hydroxyphytanoyl-CoA lyase. |
| Alternative Name: |
2-HPCL. |
3D structure
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| RHEA:25379 | 2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]-[NH;+0:12]-[*:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:11]-[N;H0;+0:12](-[*:13])-[OH;+0:14].[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids. | Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M | 1999 Aug 31 | 10468558 |
| RHEA:25375 | 2-hydroxy-3-methyl fatty acyl-CoA = 2-methyl-branched fatty aldehyde + formyl-CoA |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[*:5])-[*:6]>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:5]=[CH;+0:4]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids. | Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M | 1999 Aug 31 | 10468558 |
| RHEA:25355 | 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[C;H0;+0:4](-[*:5])=[*:6]>>[*:5]-[CH;+0:4]=[*:6].[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids. | Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M | 1999 Aug 31 | 10468558 |
| Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. | Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts GP, Van Veldhoven PP, Casteels M | 2005 Mar 18 | 15644336 |