EC number:4.1.99.23
| ID: | 4.1.99.23 |
|---|---|
| Description: | 5-hydroxybenzimidazole synthase. |
| Alternative Name: |
HBI synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.99.23 |
| BRENDA Enzyme Link: | BRENDA 4.1.99.23 |
| KEGG Enzyme Link: | KEGG4.1.99.23 |
| BioCyc Enzyme Link: | BioCyc 4.1.99.23 |
| ExPASy Enzyme Link: | ExPASy4.1.99.23 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.99.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.99.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.99.23 |
| IntEnz Enzyme Link: | IntEnz 4.1.99.23 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.99.23 |
EC number:4.1.99.23
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:53504 | 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[S+;H0:3](-[*:4])-[*:5].[*:6]-[O;H0;+0:7]-[CH2;+0:8]-[CH;+0:9]1-[O;H0;+0:10]-[CH;+0:11](-[n;H0;+0:12]2:[*:13]:[*:14]:[cH;+0:15]:[c;H0;+0:16]:2-[NH2;+0:17])-[CH;+0:18](-[OH;+0:19])-[CH;+0:20]-1-[OH;+0:21]>>[*:1]-[CH3;+0:2].[*:6]-[OH;+0:7].[*:4]-[S;H0;+0:3]-[*:5].[NH3;+0:17].[O;H0;+0:19]=[CH;+0:8]-[OH;+0:21].[OH;+0:10]-[c;H0;+0:9]1:[cH;+0:16]:[c;H0;+0:15]2:[*:14]:[*:13]:[nH;+0:12]:[c;H0;+0:11]:2:[cH;+0:18]:[cH;+0:20]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Anaerobic biosynthesis of the lower ligand of vitamin B12. | Hazra AB, Han AW, Mehta AP, Mok KC, Osadchiy V, Begley TP, Taga ME | 2015 Aug 25 | 26246619 |
| Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis. | Mehta AP, Abdelwahed SH, Fenwick MK, Hazra AB, Taga ME, Zhang Y, Ealick SE, Begley TP | 2015 Aug 26 | 26237670 |