EC number:4.1.99.5

Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.99 Other carbon-carbon lyases
ID:4.1.99.5
Description:Aldehyde oxygenase (deformylating).
Alternative Name: Aldehyde decarbonylase.
Cath: 1.20.1260.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.99.5
BRENDA Enzyme Link: BRENDA 4.1.99.5
KEGG Enzyme Link: KEGG4.1.99.5
BioCyc Enzyme Link: BioCyc 4.1.99.5
ExPASy Enzyme Link: ExPASy4.1.99.5
EC2PDB Enzyme Link: EC2PDB 4.1.99.5
ExplorEnz Enzyme Link: ExplorEnz 4.1.99.5
PRIAM enzyme-specific profiles Link: PRIAM 4.1.99.5
IntEnz Enzyme Link: IntEnz 4.1.99.5
MEDLINE Enzyme Link: MEDLINE 4.1.99.5

EC number:4.1.99.5

MSA:

4.1.99.5;
Phylogenetic Tree:

4.1.99.5;
Uniprot:
M-CSA:
RHEA:30415 H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)
RULE(radius=1) [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[CH2;+0:10]-[CH;+0:11]=[O:12].[*:13]-[N;H0;+0:14]1-[CH;+0:15]=[C;H0;+0:16](-[*:17])-[CH2;+0:18]-[CH;+0:19]=[CH;+0:20]-1.[H+;H0:21].[O;H0;+0:22]=[O;H0;+0:23]>>[*:9]-[CH3;+0:10].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:13]-[n+;H0:14]1:[cH;+0:15]:[c;H0;+0:16](-[*:17]):[cH;+0:18]:[cH;+0:19]:[cH;+0:20]:1.[O:12]=[CH;+0:11]-[OH;+0:22].[OH2;+0:23]
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References

TitleAuthorsDatePubMed ID
Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a particulate preparation from Pisum sativum.Cheesbrough TM, Kolattukudy PE1984 Nov6593720
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase.Warui DM, Li N, Nørgaard H, Krebs C, Bollinger JM Jr, Booker SJ2011 Mar 1621341652
Microbial biosynthesis of alkanes.Schirmer A, Rude MA, Li X, Popova E, del Cardayre SB2010 Jul 3020671186
RHEA:21440 a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)
RULE(radius=1) [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[*:17]=[CH;+0:18]-[*;H0;+0:19].[H+;H0:20].[O;H0;+0:21]=[O;H0;+0:22]>>[*;H0;+0:19].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[*:17]=[CH;+0:18]-[OH;+0:21].[OH2;+0:22]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Alkane biosynthesis by decarbonylation of aldehydes catalyzed by a particulate preparation from Pisum sativum.Cheesbrough TM, Kolattukudy PE1984 Nov6593720
Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases.Li N, Chang WC, Warui DM, Booker SJ, Krebs C, Bollinger JM Jr2012 Oct 922947199
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase.Warui DM, Li N, Nørgaard H, Krebs C, Bollinger JM Jr, Booker SJ2011 Mar 1621341652
Microbial biosynthesis of alkanes.Schirmer A, Rude MA, Li X, Popova E, del Cardayre SB2010 Jul 3020671186