EC number:4.2.1.10
3D structure
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1GQO;
1UQR;
2WKS;
4B6S;
4B6R;
2XD9;
2XB9;
2XDA;
2C4W;
2C4V;
1J2Y;
2CJF;
2BT4;
1V1J;
1GU1;
1GU0;
1D0I;
4KIW;
4KIU;
4KI7;
3N8N;
3N8K;
3N87;
3N86;
3N7A;
3N59;
4V0S;
4CL0;
4CIW;
4B6P;
4B6O;
3N76;
2XB8;
4CNO;
1L9W;
4CNP;
4CNN;
4CLM;
1QFE;
4UIO;
1GQN;
5YPQ;
5YL5;
5YHM;
5YDB;
5X47;
5WRF;
5SWU;
5B6P;
4ZC1;
4RHC;
4RC9;
4PH6;
4IUO;
4H3D;
4GUJ;
4GUI;
4GUH;
4GUG;
4GUF;
4GFS;
3S42;
3OEX;
3O1N;
3NNT;
3M7W;
3LWZ;
3LB0;
3L2I;
3KIP;
3JS3;
2YSW;
2UYG;
2EGZ;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.10 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.10 |
| KEGG Enzyme Link: | KEGG4.2.1.10 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.10 |
| ExPASy Enzyme Link: | ExPASy4.2.1.10 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.10 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.10 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.10 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.10 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.10 |
| RHEA:21096 | 3-dehydroquinate = 3-dehydroshikimate + H2O |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH2;+0:5]-[*:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:5]-[*:6].[OH2;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. | Cheung VW, Xue B, Hernandez-Valladares M, Go MK, Tung A, Aguda AH, Robinson RC, Yew WS | 2014 | 25072253 |
| The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor. | White PJ, Young J, Hunter IS, Nimmo HG, Coggins JR | 1990 Feb 1 | 2306211 |
| Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates. | Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A | 2011 Feb 4 | 21087925 |
| Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. | Evans LD, Roszak AW, Noble LJ, Robinson DA, Chalk PA, Matthews JL, Coggins JR, Price NC, Lapthorn AJ | 2002 Oct 23 | 12387860 |
| The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. | Roszak AW, Robinson DA, Krell T, Hunter IS, Fredrickson M, Abell C, Coggins JR, Lapthorn AJ | 2002 Apr | 11937054 |
| The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. | Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR, Hawkins AR, Isaacs NW, Sawyer L | 1999 Jun | 10360352 |