EC number:4.2.1.106
| ID: | 4.2.1.106 |
|---|---|
| Description: | Bile-acid 7-alpha-dehydratase. |
| Alternative Name: |
BA7 alpha dehydratase. |
| Cath: | 3.10.450.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.106 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.106 |
| KEGG Enzyme Link: | KEGG4.2.1.106 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.106 |
| ExPASy Enzyme Link: | ExPASy4.2.1.106 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.106 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.106 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.106 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.106 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.106 |
EC number:4.2.1.106
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10436 | 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[CH;+0:4]-[*:5].[OH2;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. | Dawson JA, Mallonee DH, Björkhem I, Hylemon PB | 1996 Jun | 8808760 |
| Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis. | Bhowmik S, Chiu HP, Jones DH, Chiu HJ, Miller MD, Xu Q, Farr CL, Ridlon JM, Wells JE, Elsliger MA, Wilson IA, Hylemon PB, Lesley SA | 2016 Mar | 26650892 |
| Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708. | Mallonee DH, White WB, Hylemon PB | 1990 Dec | 2254270 |