EC number:4.2.1.107
| ID: | 4.2.1.107 |
|---|---|
| Description: | hydratase. |
| Alternative Name: |
D-3-hydroxyacyl-CoA dehydratase. |
| Cath: | 3.30.1050.10; 3.30.160.260; 3.40.50.720; 3.10.129.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.107 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.107 |
| KEGG Enzyme Link: | KEGG4.2.1.107 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.107 |
| ExPASy Enzyme Link: | ExPASy4.2.1.107 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.107 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.107 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.107 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.107 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.107 |
EC number:4.2.1.107
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18933 | (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH;+0:4](-[*:5])-[OH;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency. | van Grunsven EG, van Berkel E, Ijlst L, Vreken P, de Klerk JB, Adamski J, Lemonde H, Clayton PT, Cuebas DA, Wanders RJ | 1998 Mar 3 | 9482850 |
| Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis. | Qin YM, Haapalainen AM, Conry D, Cuebas DA, Hiltunen JK, Novikov DK | 1997 Dec 1 | 9371691 |
| The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids. | Xu R, Cuebas DA | 1996 Apr 16 | 8619845 |
| Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis. | Kurosawa T, Sato M, Nakano H, Fujiwara M, Murai T, Yoshimura T, Hashimoto T | 2001 Feb | 11146090 |
| Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method. | Ferdinandusse S, Denis S, van Berkel E, Dacremont G, Wanders RJ | 2000 Mar | 10706581 |
| The enzymes, regulation, and genetics of bile acid synthesis. | Russell DW | 2003 | 12543708 |