EC number:4.2.1.113
| ID: | 4.2.1.113 |
|---|---|
| Description: | o-succinylbenzoate synthase. |
| Alternative Name: |
OSBS. OSB synthase. o-succinylbenzoic acid synthase. 2-succinylbenzoate synthase. |
| Cath: | 3.20.20.120; 3.30.390.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.113 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.113 |
| KEGG Enzyme Link: | KEGG4.2.1.113 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.113 |
| ExPASy Enzyme Link: | ExPASy4.2.1.113 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.113 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.113 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.113 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.113 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.113 |
EC number:4.2.1.113
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10196 | (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[C;H0;+0:3](-[*:4])=[CH;+0:5]-[CH;+0:6]=[CH;+0:7]-[CH;+0:8]-1-[OH;+0:9]>>[*:1]-[c;H0;+0:2]1:[cH;+0:8]:[cH;+0:7]:[cH;+0:6]:[cH;+0:5]:[c;H0;+0:3]:1-[*:4].[OH2;+0:9] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli. | Sharma V, Meganathan R, Hudspeth ME | 1993 Aug | 8335646 |
| Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis. | Taylor Ringia EA, Garrett JB, Thoden JB, Holden HM, Rayment I, Gerlt JA | 2004 Jan 13 | 14705949 |
| Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli. | Klenchin VA, Taylor Ringia EA, Gerlt JA, Rayment I | 2003 Dec 16 | 14661953 |
| Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. | Thompson TB, Garrett JB, Taylor EA, Meganathan R, Gerlt JA, Rayment I | 2000 Sep 5 | 10978150 |
| Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase. | Palmer DR, Garrett JB, Sharma V, Meganathan R, Babbitt PC, Gerlt JA | 1999 Apr 6 | 10194342 |