EC number:4.2.1.115

Enzyme

Download
EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.115
Description:UDP-N-acetylglucosamine 4,6-dehydratase (inverting).
Alternative Name: UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase.
Cath: 3.40.50.720; 3.90.25.30;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.115
BRENDA Enzyme Link: BRENDA 4.2.1.115
KEGG Enzyme Link: KEGG4.2.1.115
BioCyc Enzyme Link: BioCyc 4.2.1.115
ExPASy Enzyme Link: ExPASy4.2.1.115
EC2PDB Enzyme Link: EC2PDB 4.2.1.115
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.115
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.115
IntEnz Enzyme Link: IntEnz 4.2.1.115
MEDLINE Enzyme Link: MEDLINE 4.2.1.115

EC number:4.2.1.115

MSA:

4.2.1.115;
Phylogenetic Tree:

4.2.1.115;
Uniprot:
M-CSA:
RHEA:26111 UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
RULE(radius=1) [*:1]-[CH;+0:2](-[OH;+0:3])-[*:4]-[CH2;+0:5]-[OH;+0:6]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[*:4]-[CH3;+0:5].[OH2;+0:6]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Dynamic elements govern the catalytic activity of CapE, a capsular polysaccharide-synthesizing enzyme from Staphylococcus aureus.Miyafusa T, Caaveiro JM, Tanaka Y, Tsumoto K2013 Nov 2924157361
Mechanistic studies on PseB of pseudaminic acid biosynthesis: a UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase.Morrison JP, Schoenhofen IC, Tanner ME2008 Dec18845311
Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction.Schoenhofen IC, McNally DJ, Brisson JR, Logan SM2006 Sep16751642
Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity.Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, Lam JS, Berghuis AM2006 Aug 2516651261
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM2006 Jan 1316286454
Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori.Schirm M, Soo EC, Aubry AJ, Austin J, Thibault P, Logan SM2003 Jun12791140
Topological and functional characterization of WbpM, an inner membrane UDP-GlcNAc C6 dehydratase essential for lipopolysaccharide biosynthesis in Pseudomonas aeruginosa.Creuzenet C, Lam JS2001 Sep11580835