EnzyMine

Download

EC Tree

4. Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

ID:	4.2.1.128
Description:	Lupan-3-beta,20-diol synthase.

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 4.2.1.128
BRENDA Enzyme Link:	BRENDA 4.2.1.128
KEGG Enzyme Link:	KEGG4.2.1.128
BioCyc Enzyme Link:	BioCyc 4.2.1.128
ExPASy Enzyme Link:	ExPASy4.2.1.128
EC2PDB Enzyme Link:	EC2PDB 4.2.1.128
ExplorEnz Enzyme Link:	ExplorEnz 4.2.1.128
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.1.128
IntEnz Enzyme Link:	IntEnz 4.2.1.128
MEDLINE Enzyme Link:	MEDLINE 4.2.1.128

RHEA:31351	lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O
RULE(radius=1)	([:1]-[C;H0;+0:2](-[:3]-[:4]-[CH;+0:5]=[C;H0;+0:6](-[:7])-[:8])=[CH;+0:9]-[:10]-[CH2;+0:11]-[C;H0;+0:12](-[CH3;+0:13])=[CH;+0:14]-[:15]-[:16]-[CH;+0:17]=[C;H0;+0:18](-[:19])-[:20]-[:21]-[CH;+0:22]=[C;H0;+0:23](-[:24])-[:25].[:26]-[C;H0;+0:27]1(-[:28])-[:29]-[O;H0;+0:30]-1).[OH2;+0:31]>>[:1]-[C;H0;+0:2]12-[:3]-[:4]-[C;H0;+0:5]3(-[CH3;+0:13])-[CH;+0:14](-[:15]-[:16]-[CH;+0:17]4-[C;H0;+0:23](-[:24])(-[:25])-[CH;+0:22](-[C;H0;+0:27](-[:26])(-[:28])-[:29]-[OH;+0:30])-[:21]-[:20]-[C;H0;+0:18]-4-3-[:19])-[CH;+0:12]-1-[CH;+0:11](-[C;H0;+0:6](-[:7])(-[:8])-[OH;+0:31])-[:10]-[CH2;+0:9]-2
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization.	Kushiro T, Hoshino M, Tsutsumi T, Kawai K, Shiro M, Shibuya M, Ebizuka Y	2006 Nov 23	17107079
Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol.	Segura MJ, Meyer MM, Matsuda SP	2000 Jul 27	10930257