EC number:4.2.1.136

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.136
Description:ADP-dependent NAD(P)H-hydrate dehydratase.
Alternative Name: hydro-lyase(ADP-hydrolyzing).
(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide
hydro-lyase (ADP-hydrolyzing; NADH-forming).
(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide
Cath: 3.40.1190.20; 3.40.50.10260;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.136
BRENDA Enzyme Link: BRENDA 4.2.1.136
KEGG Enzyme Link: KEGG4.2.1.136
BioCyc Enzyme Link: BioCyc 4.2.1.136
ExPASy Enzyme Link: ExPASy4.2.1.136
EC2PDB Enzyme Link: EC2PDB 4.2.1.136
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.136
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.136
IntEnz Enzyme Link: IntEnz 4.2.1.136
MEDLINE Enzyme Link: MEDLINE 4.2.1.136

EC number:4.2.1.136

MSA:

4.2.1.136;
Phylogenetic Tree:

4.2.1.136;
Uniprot:
M-CSA:
RHEA:32235 (6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[O;H0;+0:10]-[*:11]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:11]-[OH;+0:10].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[OH;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair.Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL2011 Dec 221994945
RHEA:32223 (6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[O;H0;+0:10]-[*:11]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:11]-[OH;+0:10].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[OH;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair.Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL2011 Dec 221994945