EC number:4.2.1.154

Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.154
Description:Tetracenomycin F2 cyclase.
Cath: 3.30.70.1090;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.154
BRENDA Enzyme Link: BRENDA 4.2.1.154
KEGG Enzyme Link: KEGG4.2.1.154
BioCyc Enzyme Link: BioCyc 4.2.1.154
ExPASy Enzyme Link: ExPASy4.2.1.154
EC2PDB Enzyme Link: EC2PDB 4.2.1.154
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.154
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.154
IntEnz Enzyme Link: IntEnz 4.2.1.154
MEDLINE Enzyme Link: MEDLINE 4.2.1.154

EC number:4.2.1.154

MSA:

4.2.1.154;
Phylogenetic Tree:

4.2.1.154;
Uniprot:
M-CSA:
RHEA:38851 H(+) + tetracenomycin F2 = H2O + tetracenomycin F1
RULE(radius=1) [*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[*:4]:[*:5]-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[*:10].[H+;H0:11]>>[*:1]-[c;H0;+0:2]1:[*:4]:[*:5]:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[c;H0;+0:9]:1-[*:10].[OH2;+0:3]
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References

TitleAuthorsDatePubMed ID
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.Shen B, Hutchinson CR1993 Oct 198218177
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I2004 Sep 315231835