EC number:4.2.1.172

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.172
Description:Trans-4-hydroxy-L-proline dehydratase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.172
BRENDA Enzyme Link: BRENDA 4.2.1.172
KEGG Enzyme Link: KEGG4.2.1.172
BioCyc Enzyme Link: BioCyc 4.2.1.172
ExPASy Enzyme Link: ExPASy4.2.1.172
EC2PDB Enzyme Link: EC2PDB 4.2.1.172
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.172
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.172
IntEnz Enzyme Link: IntEnz 4.2.1.172
MEDLINE Enzyme Link: MEDLINE 4.2.1.172

EC number:4.2.1.172

MSA:

4.2.1.172;
Phylogenetic Tree:

4.2.1.172;
Uniprot:
M-CSA:
RHEA:54644 trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O
RULE(radius=1) [OH;+0:1]-[CH;+0:2]1-[*:3]-[*:4]-[NH;+0:5]-[CH2;+0:6]-1>>[*:4]1-[*:3]-[CH2;+0:2]-[CH;+0:6]=[N;H0;+0:5]-1.[OH2;+0:1]
Reaction
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References

TitleAuthorsDatePubMed ID
A prominent glycyl radical enzyme in human gut microbiomes metabolizes <i>trans</i>-4-hydroxy-l-proline.Levin BJ, Huang YY, Peck SC, Wei Y, Martínez-Del Campo A, Marks JA, Franzosa EA, Huttenhower C, Balskus EP2017 Feb 1028183913