EC number:4.2.1.47
| ID: | 4.2.1.47 |
|---|---|
| Description: | GDP-mannose 4,6-dehydratase. |
| Alternative Name: |
Guanosine diphosphomannose oxidoreductase. Guanosine diphosphomannose 4,6-dehydratase. Guanosine 5'-diphosphate-D-mannose oxidoreductase. GDP-D-mannose dehydratase. GDP-D-mannose 4,6-dehydratase. |
| Cath: | 3.40.50.720; 3.90.25.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.47 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.47 |
| KEGG Enzyme Link: | KEGG4.2.1.47 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.47 |
| ExPASy Enzyme Link: | ExPASy4.2.1.47 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.47 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.47 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.47 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.47 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.47 |
| RHEA:23820 | GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[*:4]-[CH2;+0:5]-[OH;+0:6]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[*:4]-[CH3;+0:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T. | Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P | 2001 Feb 23 | 11096116 |
| Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. | Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA | 1998 Apr 3 | 9525924 |
| Purification of guanosine 5'-diphosphate D-mannose oxidoreductase from Phaseolus vulgaris. | Liao TH, Barber GA | 1972 Jul 13 | 5047712 |
| The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase. | Melo A, Elliott WH, Glaser L | 1968 Apr 10 | 4869560 |
| THE BIOSYNTHESIS OF CELL WALL LIPOPOLYSACCHARIDE IN ESCHERICHIA COLI. II. GUANOSINE DIPHOSPHATE 4-KETO-6-DEOXY-D-MANNOSE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE COLITOSE. | ELBEIN AD, HEATH EC | 1965 May | 14299611 |
| Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis thaliana: implications for ligand binding and specificity. | Mulichak AM, Bonin CP, Reiter WD, Garavito RM | 2002 Dec 31 | 12501186 |