EC number:4.2.1.70

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.70
Description:Pseudouridylate synthase.
Alternative Name: Uracil hydrolyase.
Pseudouridine-5'-phosphate glycosidase.
Pseudouridine synthase.
Prosite: PDOC00885; PDOC00869;
PDB:
PDBScop
1XPI 8028846; 8041225; 8028846; 8041225;
1V9K 8028846; 8041225; 8028846; 8041225;
2IST 8028845; 8041224;
1V9F 8028845; 8041224;
1VIO 8023514; 8023515; 8035894; 8035895; 8023514; 8023515; 8035894; 8035895;
 » show all
Cath: 3.40.1790.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.70
BRENDA Enzyme Link: BRENDA 4.2.1.70
KEGG Enzyme Link: KEGG4.2.1.70
BioCyc Enzyme Link: BioCyc 4.2.1.70
ExPASy Enzyme Link: ExPASy4.2.1.70
EC2PDB Enzyme Link: EC2PDB 4.2.1.70
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.70
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.70
IntEnz Enzyme Link: IntEnz 4.2.1.70
MEDLINE Enzyme Link: MEDLINE 4.2.1.70

EC number:4.2.1.70

MSA:

4.2.1.70;
Phylogenetic Tree:

4.2.1.70;
Uniprot:
M-CSA:
RHEA:18337 D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate
RULE(radius=1) [*:1]-[CH;+0:2](-[OH;+0:3])-[*:4]-[*:5]-[CH;+0:6]=[O;H0;+0:7].[*:8]:[cH;+0:9]:[*:10]>>[*:8]:[c;H0;+0:9](:[*:10])-[CH;+0:6]1-[*:5]-[*:4]-[CH;+0:2](-[*:1])-[O;H0;+0:7]-1.[OH2;+0:3]
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References

TitleAuthorsDatePubMed ID
Enzymatic synthesis of deoxypseudouridylic acid and a study of certain of its properties.Remsen JF, Matsushita T, Chirikjian JG, Davis FF1972 Nov 94569284
Pseudouridine monophosphate glycosidase: a new glycosidase mechanism.Huang S, Mahanta N, Begley TP, Ealick SE2012 Nov 1323066817
Molecular identification of pseudouridine-metabolizing enzymes.Preumont A, Snoussi K, Stroobant V, Collet JF, Van Schaftingen E2008 Sep 1218591240