EC number:4.2.1.78
| ID: | 4.2.1.78 | ||
|---|---|---|---|
| Description: | (S)-norcoclaurine synthase. | ||
| Alternative Name: |
(S)-norlaudanosoline synthase. | ||
| Prosite: | PDOC51471; | ||
| PDB: |
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||
| Cath: | 3.30.530.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.78 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.78 |
| KEGG Enzyme Link: | KEGG4.2.1.78 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.78 |
| ExPASy Enzyme Link: | ExPASy4.2.1.78 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.78 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.78 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.78 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.78 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.78 |
| RHEA:16173 | (4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[O;H0;+0:3].([*:4]-[NH2;+0:5].[*:6]:[cH;+0:7]:[*:8])>>[*:4]-[NH;+0:5]-[CH;+0:2](-[*:1])-[c;H0;+0:7](:[*:6]):[*:8].[OH2;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis of enzymatic (S)-norcoclaurine biosynthesis. | Ilari A, Franceschini S, Bonamore A, Arenghi F, Botta B, Macone A, Pasquo A, Bellucci L, Boffi A | 2009 Jan 9 | 19004827 |
| Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction. | Luk LY, Bunn S, Liscombe DK, Facchini PJ, Tanner ME | 2007 Sep 4 | 17696451 |
| Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms. | Liscombe DK, Macleod BP, Loukanina N, Nandi OI, Facchini PJ | 2005 Jun | 15925393 |
| Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis. | Samanani N, Liscombe DK, Facchini PJ | 2004 Oct | 15447655 |
| Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants. | Samanani N, Facchini PJ | 2002 Sep 13 | 12107162 |
| Isolation and partial characterization of norcoclaurine synthase, the first committed step in benzylisoquinoline alkaloid biosynthesis, from opium poppy. | Samanani N, Facchini PJ | 2001 Oct | 11722126 |