EC number:4.2.3.12
| ID: | 4.2.3.12 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Description: | 6-pyruvoyltetrahydropterin synthase. | ||||||||||||
| Alternative Name: |
PTPS. 6-pyruvoyl tetrahydrobiopterin synthase. | ||||||||||||
| Prosite: | PDOC00759; | ||||||||||||
| PDB: |
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| Cath: | 1.10.286.10; 3.30.1130.10; 3.30.479.10; 3.10.270.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.12 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.12 |
| KEGG Enzyme Link: | KEGG4.2.3.12 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.12 |
| ExPASy Enzyme Link: | ExPASy4.2.3.12 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.12 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.12 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.12 |
| RHEA:22048 | 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]=[C;H0;+0:3](-[*:4])-[CH;+0:5](-[OH;+0:6])-[CH;+0:7](-[OH;+0:8])-[CH2;+0:9]-[O;H0;+0:10]-[*:11]>>[*:1]-[NH;+0:2]-[CH;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[CH3;+0:9])=[O;H0;+0:8].[*:11]-[OH;+0:10] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. | Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH | 2005 Feb 1 | 16510994 |
| Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase. | Bracher A, Eisenreich W, Schramek N, Ritz H, Götze E, Herrmann A, Gütlich M, Bacher A | 1998 Oct 23 | 9774432 |
| Biosynthesis of biopterin. Studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase. | Le Van Q, Katzenmeier G, Schwarzkopf B, Schmid C, Bacher A | 1988 Feb 29 | 3279951 |
| Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme. | Thöny B, Leimbacher W, Bürgisser D, Heizmann CW | 1992 Dec 30 | 1282802 |
| Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase. | Ploom T, Thöny B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G | 1999 Feb 26 | 10024455 |