EC number:4.2.3.5

Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.5
Description:Chorismate synthase.
Alternative Name: 5-enolpyruvylshikimate-3-phosphate phospholyase.
Prosite: PDOC00628;
PDB:
PDBScop
1SQ1 8029275; 8041654;
1UMF 8028548; 8040927; 8028548; 8040927; 8028548; 8040927; 8028548; 8040927;
1UM0 8028548; 8040927; 8028548; 8040927; 8028548; 8040927; 8028548; 8040927;
1R52 8027955; 8040334; 8027955; 8040334; 8027955; 8040334; 8027955; 8040334;
1R53 8027955; 8040334;
 » show all
Cath: 3.60.150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.5
BRENDA Enzyme Link: BRENDA 4.2.3.5
KEGG Enzyme Link: KEGG4.2.3.5
BioCyc Enzyme Link: BioCyc 4.2.3.5
ExPASy Enzyme Link: ExPASy4.2.3.5
EC2PDB Enzyme Link: EC2PDB 4.2.3.5
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.5
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.5
IntEnz Enzyme Link: IntEnz 4.2.3.5
MEDLINE Enzyme Link: MEDLINE 4.2.3.5

EC number:4.2.3.5

MSA:

4.2.3.5;
Phylogenetic Tree:

4.2.3.5;
Uniprot:
M-CSA:
RHEA:21020 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3]1-[*:4]-[*:5]-[CH2;+0:6]-[C;H0;+0:7](-[*:8])=[CH;+0:9]-1>>[*:8]-[C;H0;+0:7]1=[CH;+0:6]-[*:5]-[*:4]-[CH;+0:3]=[CH;+0:9]-1.[*:1]-[OH;+0:2]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The transient kinetics of Escherichia coli chorismate synthase: substrate consumption, product formation, phosphate dissociation, and characterization of a flavin intermediate.Bornemann S, Lowe DJ, Thorneley RN1996 Jul 308703965
The enzymic synthesis of chorismic and prephenic acids from 3-enolpyruvylshikimic acid 5-phosphate.Morell H, Clark MJ, Knowles PF, Sprinson DB1967 Jan 104289188
Chorismate synthase of Neurospora crassa: a flavoprotein.Welch GR, Cole KW, Gaertner FH1974 Dec4155270
Properties of chorismate synthase in Neurospora crassa.Gaertner FH, Cole KW1973 Jul 104146266
A Secondary beta Deuterium Kinetic Isotope Effect in the Chorismate Synthase Reaction.Bornemann S, Theoclitou ME, Brune M, Webb MR, Thorneley RN, Abell C2000 Aug11034781
Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction.Osborne A, Thorneley RN, Abell C, Bornemann S2000 Nov 1710956653