EC number:4.6.1.1
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.6 Phosphorus-oxygen lyases |
| 4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date) |
3D structure
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1FX4;
2WZ1;
3UVJ;
4NI2;
4P2X;
4P2M;
4P2F;
1YK9;
3MAA;
3C15;
2GVD;
1U0H;
1FX2;
3C16;
1CJT;
1AB8;
3G82;
3C14;
2GVZ;
1TL7;
1CUL;
1CS4;
1CJV;
1CJU;
1CJK;
1AZS;
5IV4;
5IV3;
5D0R;
4USW;
4USV;
4USU;
4UST;
4OZ3;
4OZ2;
4OYZ;
4OYX;
4OYW;
4OYP;
4OYO;
4OYM;
4OYI;
4OYB;
4OYA;
4CM2;
4CM0;
4CLZ;
4CLY;
4CLW;
4CLU;
4CLT;
4CLS;
4CLP;
4CLL;
4CLK;
4CLF;
3CB8;
3C8F;
1Y11;
1Y10;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 4.6.1.1 |
| BRENDA Enzyme Link: | BRENDA 4.6.1.1 |
| KEGG Enzyme Link: | KEGG4.6.1.1 |
| BioCyc Enzyme Link: | BioCyc 4.6.1.1 |
| ExPASy Enzyme Link: | ExPASy4.6.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 4.6.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.6.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.6.1.1 |
| IntEnz Enzyme Link: | IntEnz 4.6.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 4.6.1.1 |
| RHEA:15389 | ATP = 3',5'-cyclic AMP + diphosphate |
| RULE(radius=1) | ([*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8])>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. | Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR | 1997 Dec 12 | 9417641 |
| Cloning and expression of a widely distributed (type IV) adenylyl cyclase. | Gao BN, Gilman AG | 1991 Nov 15 | 1946437 |
| Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. | Feinstein PG, Schrader KA, Bakalyar HA, Tang WJ, Krupinski J, Gilman AG, Reed RR | 1991 Nov 15 | 1719547 |
| Raf kinase activation of adenylyl cyclases: isoform-selective regulation. | Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD | 2004 Oct | 15385642 |
| Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain. | Linder JU, Schultz A, Schultz JE | 2002 May 3 | 11839758 |
| Two-metal-Ion catalysis in adenylyl cyclase. | Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR | 1999 Jul 30 | 10427002 |