EC number:4.6.1.14
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.6 Phosphorus-oxygen lyases |
| 4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date) |
| ID: | 4.6.1.14 |
|---|---|
| Description: | Glycosylphosphatidylinositol diacylglycerol-lyase. |
| Alternative Name: |
VSG-lipase. Variant-surface-glycoprotein phospholipase C. GPI-specific phospholipase C. GPI-PLC. Glycosylphosphatidylinositol-specific phospholipase C. Glycosylphosphatidylinositol-phospholipase C. Glycosyl inositol phospholipid anchor-hydrolyzing enzyme. lyase (1,2-cyclic-phosphate-forming). 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol- (Glycosyl)phosphatidylinositol-specific phospholipase C. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.6.1.14 |
| BRENDA Enzyme Link: | BRENDA 4.6.1.14 |
| KEGG Enzyme Link: | KEGG4.6.1.14 |
| BioCyc Enzyme Link: | BioCyc 4.6.1.14 |
| ExPASy Enzyme Link: | ExPASy4.6.1.14 |
| EC2PDB Enzyme Link: | EC2PDB 4.6.1.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.6.1.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.6.1.14 |
| IntEnz Enzyme Link: | IntEnz 4.6.1.14 |
| MEDLINE Enzyme Link: | MEDLINE 4.6.1.14 |
| RHEA:14333 | a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol |
| RULE(radius=1) | ([*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8])>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mutagenesis study of the glycosylphosphatidylinositol phospholipase C of Trypanosoma brucei. | Carnall N, Webb H, Carrington M | 1997 Dec 15 | 9476790 |
| A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein. | Hereld D, Krakow JL, Bangs JD, Hart GW, Englund PT | 1986 Oct 15 | 3759991 |
| Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei. | Armah DA, Mensa-Wilmot K | 2000 Jun 23 | 10764777 |