| EC Tree |
| 4. Lyases |
| 4.99 Other lyases |
| 4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses |
| ID: | 4.99.1.8 |
|---|---|
| Description: | Heme ligase. |
| Alternative Name: |
Hemozoin synthase. |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.| UniProtKB Enzyme Link: | UniProtKB 4.99.1.8 |
| BRENDA Enzyme Link: | BRENDA 4.99.1.8 |
| KEGG Enzyme Link: | KEGG4.99.1.8 |
| BioCyc Enzyme Link: | BioCyc 4.99.1.8 |
| ExPASy Enzyme Link: | ExPASy4.99.1.8 |
| EC2PDB Enzyme Link: | EC2PDB 4.99.1.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.99.1.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.99.1.8 |
| IntEnz Enzyme Link: | IntEnz 4.99.1.8 |
| MEDLINE Enzyme Link: | MEDLINE 4.99.1.8 |
| RHEA:53712 | 2 Fe(III)heme b = beta-hematin |
| RULE(radius=1) | ([*:1]-[Fe-;H0:2](-[*:3])(-[*:4])-[*:5].[*:6]-[OH;+0:7]).([*:8]-[Fe-;H0:9](-[*:10])(-[*:11])-[*:12].[*:13]-[OH;+0:14])>>([*:1]-[Fe-2:2](-[*:3])(-[*:4])(-[*:5])-[O;H0;+0:14]-[*:13].[*:6]-[O;H0;+0:7]-[Fe-2:9](-[*:8])(-[*:10])(-[*:11])-[*:12]) |
| Reaction | ![]() |
| Core-to-Core |
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| HDP-a novel heme detoxification protein from the malaria parasite. | Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D | 2008 Apr 25 | 18437218 |