EC number:5.4.99.8
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.99 Transferring other groups |
| ID: | 5.4.99.8 | ||
|---|---|---|---|
| Description: | Cycloartenol synthase. | ||
| Alternative Name: |
2,3-epoxysqualene--cycloartenol cyclase. | ||
| Prosite: | PDOC00825; | ||
| PDB: |
|
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.99.8 |
| BRENDA Enzyme Link: | BRENDA 5.4.99.8 |
| KEGG Enzyme Link: | KEGG5.4.99.8 |
| BioCyc Enzyme Link: | BioCyc 5.4.99.8 |
| ExPASy Enzyme Link: | ExPASy5.4.99.8 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.99.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.99.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.99.8 |
| IntEnz Enzyme Link: | IntEnz 5.4.99.8 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.99.8 |
| RHEA:21308 | (S)-2,3-epoxysqualene = cycloartenol |
| RULE(radius=1) | ([*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8])=[CH;+0:9]-[*:10]-[*:11]-[CH;+0:12]=[C;H0;+0:13](-[CH3;+0:14])-[*:15]-[*:16]-[CH;+0:17]=[C;H0;+0:18](-[*:19])-[CH3;+0:20].[*:21]-[C;H0;+0:22]1(-[*:23])-[*:24]-[O;H0;+0:25]-1)>>[*:1]-[C;H0;+0:2]12-[*:3]-[*:4]-[CH;+0:5](-[CH;+0:6](-[*:7])-[*:8])-[C;H0;+0:9]-1(-[CH3;+0:14])-[*:10]-[*:11]-[C;H0;+0:12]13-[CH2;+0:20]-[C;H0;+0:18]-1(-[*:19])-[CH;+0:17](-[C;H0;+0:22](-[*:21])(-[*:23])-[*:24]-[OH;+0:25])-[*:16]-[*:15]-[CH;+0:13]-3-2 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. | Kushiro T, Shibuya M, Ebizuka Y | 1998 Aug 15 | 9746369 |
| Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids. | Wang Z, Yeats T, Han H, Jetter R | 2010 Sep 24 | 20610397 |
| Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis. | Guhling O, Hobl B, Yeats T, Jetter R | 2006 Apr 15 | 16445885 |
| Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants. | Zhang H, Shibuya M, Yokota S, Ebizuka Y | 2003 May | 12736505 |