Enzyme

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     5. Isomerases
        5.5 Intramolecular lyases
            5.5.1 Intramolecular lyases (only sub-subclass identified to date)
ID:5.5.1.31
Description:Hapalindole H synthase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 5.5.1.31
BRENDA Enzyme Link: BRENDA 5.5.1.31
KEGG Enzyme Link: KEGG5.5.1.31
BioCyc Enzyme Link: BioCyc 5.5.1.31
ExPASy Enzyme Link: ExPASy5.5.1.31
EC2PDB Enzyme Link: EC2PDB 5.5.1.31
ExplorEnz Enzyme Link: ExplorEnz 5.5.1.31
PRIAM enzyme-specific profiles Link: PRIAM 5.5.1.31
IntEnz Enzyme Link: IntEnz 5.5.1.31
MEDLINE Enzyme Link: MEDLINE 5.5.1.31
MSA:

5.5.1.31;

Phylogenetic Tree:

5.5.1.31;

Uniprot:
M-CSA:
RHEA:30663 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H
RULE(radius=1) [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH3;+0:8])=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11]1(-[CH;+0:12]=[CH;+0:13]-[*:14])-[CH;+0:15]=[N;H0;+0:16]-[c;H0;+0:17]2:[*:18]:[*:19]:[cH;+0:20]:[cH;+0:21]:[c;H0;+0:22]:2-1>>[*:1]-[C;H0;+0:2]1(-[CH3;+0:21])-[CH;+0:3]2-[*:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])(-[CH;+0:8]=[CH2;+0:22])-[CH;+0:13](-[*:14])-[CH;+0:12]-2-[c;H0;+0:11]2:[cH;+0:15]:[nH;+0:16]:[c;H0;+0:17]3:[*:18]:[*:19]:[cH;+0:20]:[c;H0;+0:9]-1:[c;H0;+0:10]:2:3
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References

TitleAuthorsDatePubMed ID
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH2017 May28288107