Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.28
Description:3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase.
Alternative Name: DHCA-CoA ligase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.28
BRENDA Enzyme Link: BRENDA 6.2.1.28
KEGG Enzyme Link: KEGG6.2.1.28
BioCyc Enzyme Link: BioCyc 6.2.1.28
ExPASy Enzyme Link: ExPASy6.2.1.28
EC2PDB Enzyme Link: EC2PDB 6.2.1.28
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.28
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.28
IntEnz Enzyme Link: IntEnz 6.2.1.28
MEDLINE Enzyme Link: MEDLINE 6.2.1.28
MSA:

6.2.1.28;

Phylogenetic Tree:

6.2.1.28;

Uniprot:
M-CSA:
RHEA:21776 (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11]
Reaction
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References

TitleAuthorsDatePubMed ID
Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver.Prydz K, Kase BF, Björkhem I, Pedersen JI1988 Aug3183523