EC number:6.2.1.42

Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.42
Description:3-oxocholest-4-en-26-oate--CoA ligase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.42
BRENDA Enzyme Link: BRENDA 6.2.1.42
KEGG Enzyme Link: KEGG6.2.1.42
BioCyc Enzyme Link: BioCyc 6.2.1.42
ExPASy Enzyme Link: ExPASy6.2.1.42
EC2PDB Enzyme Link: EC2PDB 6.2.1.42
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.42
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.42
IntEnz Enzyme Link: IntEnz 6.2.1.42
MEDLINE Enzyme Link: MEDLINE 6.2.1.42

EC number:6.2.1.42

MSA:

6.2.1.42;
Phylogenetic Tree:

6.2.1.42;
Uniprot:
M-CSA:
RHEA:29291 (25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[*:11]-[SH;+0:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[S;H0;+0:12]-[*:11].[*:10]-[OH;+0:9].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[OH;+0:4]
Reaction
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References

TitleAuthorsDatePubMed ID
FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains.Wilbrink MH, Petrusma M, Dijkhuizen L, van der Geize R2011 Jul21602385
Actinobacterial acyl coenzyme A synthetases involved in steroid side-chain catabolism.Casabon I, Swain K, Crowe AM, Eltis LD, Mohn WW2014 Feb24244004