EC number:6.3.1.15

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.1 Acid-D-ammonia (or amine) ligases (amide synthases)
ID:6.3.1.15
Description:8-demethylnovobiocic acid synthase.
Alternative Name: Novobiocin ligase.
8-demethylnovobiocic acid synthetase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.1.15
BRENDA Enzyme Link: BRENDA 6.3.1.15
KEGG Enzyme Link: KEGG6.3.1.15
BioCyc Enzyme Link: BioCyc 6.3.1.15
ExPASy Enzyme Link: ExPASy6.3.1.15
EC2PDB Enzyme Link: EC2PDB 6.3.1.15
ExplorEnz Enzyme Link: ExplorEnz 6.3.1.15
PRIAM enzyme-specific profiles Link: PRIAM 6.3.1.15
IntEnz Enzyme Link: IntEnz 6.3.1.15
MEDLINE Enzyme Link: MEDLINE 6.3.1.15

EC number:6.3.1.15

MSA:

6.3.1.15;
Phylogenetic Tree:

6.3.1.15;
Uniprot:
M-CSA:
RHEA:36699 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[P;H0;+0:5](-[*:6])(=[*:7])-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:3]-[OH;+0:4].[*:6]-[P;H0;+0:5](=[*:7])(-[*:8])-[OH;+0:12].[*:9]=[C;H0;+0:10](-[*:11])-[NH;+0:2]-[*:1]
Reaction
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References

TitleAuthorsDatePubMed ID
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis.Pacholec M, Tao J, Walsh CT2005 Nov 1516274243
Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton.Pi N, Meyers CL, Pacholec M, Walsh CT, Leary JA2004 Jul 615218104
Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891.Steffensky M, Li SM, Heide L2000 Jul 1410801869