EC number:6.3.3.2
| ID: | 6.3.3.2 |
|---|---|
| Description: | 5-formyltetrahydrofolate cyclo-ligase. |
| Alternative Name: |
Methenyl-THF synthetase. 5-Formyltetrahydrofolate cyclodehydrase. 5,10-methenyltetrahydrofolate synthetase. |
| Cath: | 3.40.50.10420; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.3.2 |
| BRENDA Enzyme Link: | BRENDA 6.3.3.2 |
| KEGG Enzyme Link: | KEGG6.3.3.2 |
| BioCyc Enzyme Link: | BioCyc 6.3.3.2 |
| ExPASy Enzyme Link: | ExPASy6.3.3.2 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.3.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.3.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.3.2 |
| IntEnz Enzyme Link: | IntEnz 6.3.3.2 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.3.2 |
| RHEA:10488 | 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3]-[*:4]-[N;H0;+0:5](-[*:6])-[CH;+0:7]=[O;H0;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14]>>[*:1]-[N;H0;+0:2]1-[*:3]-[*:4]-[N+;H0:5](-[*:6])=[CH;+0:7]-1.[*:14]-[OH;+0:13].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of the human 5,10-methenyltetrahydrofolate synthetase-encoding cDNA. | Dayan A, Bertrand R, Beauchemin M, Chahla D, Mamo A, Filion M, Skup D, Massie B, Jolivet J | 1995 Nov 20 | 8522195 |
| Primary structure and tetrahydropteroylglutamate binding site of rabbit liver cytosolic 5,10-methenyltetrahydrofolate synthetase. | Maras B, Stover P, Valiante S, Barra D, Schirch V | 1994 Jul 15 | 8034591 |
| Metabolite damage and its repair or pre-emption. | Linster CL, Van Schaftingen E, Hanson AD | 2013 Feb | 23334546 |
| The metabolic role of leucovorin. | Stover P, Schirch V | 1993 Mar | 8480361 |