EC number:6.6.1.1
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.6 Forming nitrogen-D-metal bonds |
| 6.6.1 Forming coordination complexes |
| ID: | 6.6.1.1 |
|---|---|
| Description: | Magnesium chelatase. |
| Alternative Name: |
Protoporphyrin IX Mg-chelatase. Protoporphyrin IX magnesium-chelatase. Mg-protoporphyrin IX magnesio-lyase. Mg-protoporphyrin IX chelatase. Mg-chelatase. Magnesium-protoporphyrin IX chelatase. Magnesium-protoporphyrin chelatase. Magnesium-chelatase. |
| Cath: | 1.10.8.80; 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.6.1.1 |
| BRENDA Enzyme Link: | BRENDA 6.6.1.1 |
| KEGG Enzyme Link: | KEGG6.6.1.1 |
| BioCyc Enzyme Link: | BioCyc 6.6.1.1 |
| ExPASy Enzyme Link: | ExPASy6.6.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 6.6.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.6.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.6.1.1 |
| IntEnz Enzyme Link: | IntEnz 6.6.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 6.6.1.1 |
| RHEA:13961 | ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[c;H0;+0:3]2:[cH;+0:4]:[c;H0;+0:5]3:[*:6]:[*:7]:[c;H0;+0:8](:[cH;+0:9]:[c;H0;+0:10]4:[n;H0;+0:11]:[c;H0;+0:12](:[cH;+0:13]:[*:14]:[nH;+0:15]:[*:16]:[cH;+0:17]:[c;H0;+0:18](:[n;H0;+0:19]:2):[c;H0;+0:20]:1-[*:21]):[c;H0;+0:22](-[*:23]):[c;H0;+0:24]:4-[*:25]):[nH;+0:26]:3.[*:27]=[P;H0;+0:28](-[*:29])(-[*:30])-[O;H0;+0:31]-[*:32].[Mg+2;H0:33].[OH2;+0:34]>>[*:1]-[C;H0;+0:2]1=[C;H0;+0:20](-[*:21])-[C;H0;+0:18]2=[CH;+0:17]-[*:16]:[n;H0;+0:15]3:[*:14]-[CH;+0:13]=[C;H0;+0:12]4-[N;H0;+0:11]=[C;H0;+0:10](-[CH;+0:9]=[c;H0;+0:8]5:[*:7]:[*:6]:[c;H0;+0:5](:[n;H0;+0:26]:5-[Mg;H0;+0:33]-3)=[CH;+0:4]-[C;H0;+0:3]-1=[N;H0;+0:19]-2)-[C;H0;+0:24](-[*:25])=[C;H0;+0:22]-4-[*:23].[*:32]-[OH;+0:31].[*:27]=[P;H0;+0:28](-[*:29])(-[*:30])-[OH;+0:34] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism and regulation of Mg-chelatase. | Walker CJ, Willows RD | 1997 Oct 15 | 9359397 |
| Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase. | Fodje MN, Hansson A, Hansson M, Olsen JG, Gough S, Willows RD, Al-Karadaghi S | 2001 Aug 3 | 11469861 |