EC number:7.2.1.1
Enzyme
Download| EC Tree |
| 7. Translocases |
| 7.2 Catalysing the translocation of inorganic cations |
| 7.2.1 Linked to oxidoreductase reactions |
| ID: | 7.2.1.1 |
|---|---|
| Description: | NADH:ubiquinone reductase (Na(+)-transporting). |
| Alternative Name: |
Na(+)-translocating NADH-quinone reductase. Na(+)-NQR. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 7.2.1.1 |
| BRENDA Enzyme Link: | BRENDA 7.2.1.1 |
| KEGG Enzyme Link: | KEGG7.2.1.1 |
| BioCyc Enzyme Link: | BioCyc 7.2.1.1 |
| ExPASy Enzyme Link: | ExPASy7.2.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 7.2.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 7.2.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 7.2.1.1 |
| IntEnz Enzyme Link: | IntEnz 7.2.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 7.2.1.1 |
| RHEA:47748 | a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]-[N;H0;+0:14]1-[CH;+0:15]=[C;H0;+0:16](-[*:17])-[CH2;+0:18]-[CH;+0:19]=[CH;+0:20]-1.[H+;H0:21]>>[*:1]-[c;H0;+0:2]1:[c;H0;+0:11](-[OH;+0:12]):[c;H0;+0:9](-[*:10]):[c;H0;+0:7](-[*:8]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:3]:1-[*:4].[*:13]-[n+;H0:14]1:[cH;+0:15]:[c;H0;+0:16](-[*:17]):[cH;+0:18]:[cH;+0:19]:[cH;+0:20]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of six subunits constituting Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus. | Nakayama Y, Hayashi M, Unemoto T | 1998 Jan 30 | 9490015 |
| Cloning and sequencing of four structural genes for the Na(+)-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus. | Beattie P, Tan K, Bourne RM, Leach D, Rich PR, Ward FB | 1994 Dec 19 | 7805867 |
| Mutagenesis study of the 2Fe-2S center and the FAD binding site of the Na(+)-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. | Barquera B, Nilges MJ, Morgan JE, Ramirez-Silva L, Zhou W, Gennis RB | 2004 Sep 28 | 15379571 |
| Purification and characterization of the recombinant Na(+)-translocating NADH:quinone oxidoreductase from Vibrio cholerae. | Barquera B, Hellwig P, Zhou W, Morgan JE, Häse CC, Gosink KK, Nilges M, Bruesehoff PJ, Roth A, Lancaster CR, Gennis RB | 2002 Mar 19 | 11888296 |
| Sodium-dependent steps in the redox reactions of the Na+-motive NADH:quinone oxidoreductase from Vibrio harveyi. | Bogachev AV, Bertsova YV, Barquera B, Verkhovsky MI | 2001 Jun 19 | 11401580 |