EC number:1.1.1.1

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.1
Description:Alcohol dehydrogenase.
Alternative Name: Aldehyde reductase.
Prosite: PDOC00060; PDOC00058; PDOC00059;
PDB:
PDBScop
5BR4 8026548; 8038927; 8026548; 8038927;
2BL4 8026548; 8038927; 8026548; 8038927;
2BI4 8026548; 8038927; 8026548; 8038927;
1RRM 8026548; 8038927; 8026548; 8038927;
1KQ3 8026000; 8038379;
 » show all
Cath: 1.20.1090.10; 3.40.50.720; 3.40.605.10; 3.90.180.10; 3.40.309.10; 3.40.50.1970;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.1
BRENDA Enzyme Link: BRENDA 1.1.1.1
KEGG Enzyme Link: KEGG1.1.1.1
BioCyc Enzyme Link: BioCyc 1.1.1.1
ExPASy Enzyme Link: ExPASy1.1.1.1
EC2PDB Enzyme Link: EC2PDB 1.1.1.1
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.1
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.1
IntEnz Enzyme Link: IntEnz 1.1.1.1
MEDLINE Enzyme Link: MEDLINE 1.1.1.1

EC number:1.1.1.1

MSA:

1.1.1.1;
Phylogenetic Tree:

1.1.1.1;
Uniprot:
M-CSA:
RHEA:10736 a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH
RULE(radius=1) [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1
Reaction
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References

TitleAuthorsDatePubMed ID
The enzymatic reduction of retinal to retinol in rat intestine.Fidge NH, Goodman DS1968 Aug 254300551
Purification and molecular characterization of the NAD(+)-dependent acetaldehyde/alcohol dehydrogenase from Entamoeba histolytica.Bruchhaus I, Tannich E1994 Nov 17980441
Entamoeba histolytica has an alcohol dehydrogenase homologous to the multifunctional adhE gene product of Escherichia coli.Yang W, Li E, Kairong T, Stanley SL Jr1994 Apr7935603
Formaldehyde dehydrogenase from Pseudomonas putida: a zinc metalloenzyme.Ogushi S, Ando M, Tsuru D1984 Nov6526822
A multifunctional fermentative alcohol dehydrogenase from the strict aerobe Alcaligenes eutrophus: purification and properties.Steinbüchel A, Schlegel HG1984 Jun 156378632
Isolation and biochemical analysis of ethyl methanesulfonate-induced alcohol dehydrogenase null mutants of arabidopsis thaliana (L.) Heynh.Jacobs M, Dolferus R, Van den Bossche D1988 Feb3377754
Purification and enzymatic characterization of alcohol dehydrogenase from Arabidopsis thaliana.Cheng F, Hu T, An Y, Huang J, Xu Y2013 Aug23707506
Characterization of alcohol dehydrogenase genes of derepressible wild-type Alcaligenes eutrophus H16 and constitutive mutants.Jendrossek D, Krüger N, Steinbüchel A1990 Sep2144274
RHEA:10740 a secondary alcohol + NAD(+) = a ketone + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Purification and molecular characterization of the NAD(+)-dependent acetaldehyde/alcohol dehydrogenase from Entamoeba histolytica.Bruchhaus I, Tannich E1994 Nov 17980441
Entamoeba histolytica has an alcohol dehydrogenase homologous to the multifunctional adhE gene product of Escherichia coli.Yang W, Li E, Kairong T, Stanley SL Jr1994 Apr7935603
Formaldehyde dehydrogenase from Pseudomonas putida: a zinc metalloenzyme.Ogushi S, Ando M, Tsuru D1984 Nov6526822
A multifunctional fermentative alcohol dehydrogenase from the strict aerobe Alcaligenes eutrophus: purification and properties.Steinbüchel A, Schlegel HG1984 Jun 156378632
Isolation and biochemical analysis of ethyl methanesulfonate-induced alcohol dehydrogenase null mutants of arabidopsis thaliana (L.) Heynh.Jacobs M, Dolferus R, Van den Bossche D1988 Feb3377754
Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects.Jörnvall H1977 Feb320001
Purification and enzymatic characterization of alcohol dehydrogenase from Arabidopsis thaliana.Cheng F, Hu T, An Y, Huang J, Xu Y2013 Aug23707506
Characterization of alcohol dehydrogenase genes of derepressible wild-type Alcaligenes eutrophus H16 and constitutive mutants.Jendrossek D, Krüger N, Steinbüchel A1990 Sep2144274
Kinetics and equilibria in the liver alcohol dehydrogenase system.THEORELL H195813605979
RHEA:25290 ethanol + NAD(+) = acetaldehyde + H(+) + NADH
RULE(radius=1) [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1
Reaction
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