EC number:1.1.1.102
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.102 |
|---|---|
| Description: | 3-dehydrosphinganine reductase. |
| Alternative Name: |
KTS reductase. DSR. D-3-oxosphinganine:B-NADPH oxidoreductase. D-3-oxosphinganine reductase. D-3-dehydrosphinganine reductase. 3-oxosphinganine:NADPH oxidoreductase. 3-oxosphinganine reductase. 3-ketosphinganine reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.102 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.102 |
| KEGG Enzyme Link: | KEGG1.1.1.102 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.102 |
| ExPASy Enzyme Link: | ExPASy1.1.1.102 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.102 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.102 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.102 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.102 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.102 |
EC number:1.1.1.102
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:22640 | NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. | Beeler T, Bacikova D, Gable K, Hopkins L, Johnson C, Slife H, Dunn T | 1998 Nov 13 | 9804843 |
| Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one). | Stoffel W, LeKim D, Sticht G | 1968 Dec | 4387676 |
| Biosynthesis of dihydrosphingosine in vitro. | Stoffel W, LeKim D, Sticht G | 1968 May | 4386961 |
| Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. | Chao DY, Gable K, Chen M, Baxter I, Dietrich CR, Cahoon EB, Guerinot ML, Lahner B, Lü S, Markham JE, Morrissey J, Han G, Gupta SD, Harmon JM, Jaworski JG, Dunn TM, Salt DE | 2011 Mar | 21421810 |
| FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. | Kihara A, Igarashi Y | 2004 Nov 19 | 15328338 |