EC number:1.1.1.105
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.105 | ||
|---|---|---|---|
| Description: | All-trans-retinol dehydrogenase (NAD(+)). | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.105 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.105 |
| KEGG Enzyme Link: | KEGG1.1.1.105 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.105 |
| ExPASy Enzyme Link: | ExPASy1.1.1.105 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.105 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.105 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.105 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.105 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.105 |
EC number:1.1.1.105
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:48488 | all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Retinol and alcohol dehydrogenases in retina and liver. | Koen AL, Shaw CR | 1966 Oct 17 | 5972368 |
| Biochemical characterization of human epidermal retinol dehydrogenase 2. | Lee SA, Belyaeva OV, Kedishvili NY | 2009 Mar 16 | 18926804 |
| Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. | Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, Inoko H | 2002 Oct 11 | 12372410 |
| cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. | Gough WH, VanOoteghem S, Sint T, Kedishvili NY | 1998 Jul 31 | 9677409 |
| RHEA:21284 | all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase. | Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY | 2001 Feb 1 | 11360992 |
| cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. | Gough WH, VanOoteghem S, Sint T, Kedishvili NY | 1998 Jul 31 | 9677409 |
| Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase. | Allali-Hassani A, Peralba JM, Martras S, Farrés J, Parés X | 1998 Apr 24 | 9600267 |
| Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism. | Hellgren M, Strömberg P, Gallego O, Martras S, Farrés J, Persson B, Parés X, Höög JO | 2007 Feb | 17279314 |
| Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. | Gallego O, Belyaeva OV, Porté S, Ruiz FX, Stetsenko AV, Shabrova EV, Kostereva NV, Farrés J, Parés X, Kedishvili NY | 2006 Oct 1 | 16787387 |
| Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80. | Martras S, Alvarez R, Gallego O, Domínguez M, de Lera AR, Farrés J, Parés X | 2004 Oct 15 | 15369820 |