EC number:1.1.1.130
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.130 |
|---|---|
| Description: | 3-dehydro-L-gulonate 2-dehydrogenase. |
| Alternative Name: |
3-keto-L-gulonate dehydrogenase. 2,3-diketo-L-gulonate reductase. |
| Cath: | 1.10.1530.10; 3.30.1370.60; 3.30.60.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.130 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.130 |
| KEGG Enzyme Link: | KEGG1.1.1.130 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.130 |
| ExPASy Enzyme Link: | ExPASy1.1.1.130 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.130 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.130 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.130 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.130 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.130 |
EC number:1.1.1.130
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21928 | 3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK). | Forouhar F, Lee I, Benach J, Kulkarni K, Xiao R, Acton TB, Montelione GT, Tong L | 2004 Mar 26 | 14718529 |
| RHEA:21924 | 3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK). | Forouhar F, Lee I, Benach J, Kulkarni K, Xiao R, Acton TB, Montelione GT, Tong L | 2004 Mar 26 | 14718529 |