EC number:1.1.1.132

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.132
Description:GDP-mannose 6-dehydrogenase.
Cath: 1.20.5.170; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.132
BRENDA Enzyme Link: BRENDA 1.1.1.132
KEGG Enzyme Link: KEGG1.1.1.132
BioCyc Enzyme Link: BioCyc 1.1.1.132
ExPASy Enzyme Link: ExPASy1.1.1.132
EC2PDB Enzyme Link: EC2PDB 1.1.1.132
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.132
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.132
IntEnz Enzyme Link: IntEnz 1.1.1.132
MEDLINE Enzyme Link: MEDLINE 1.1.1.132

EC number:1.1.1.132

MSA:

1.1.1.132;
Phylogenetic Tree:

1.1.1.132;
Uniprot:
M-CSA:
RHEA:21728 GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]-[c;H0;+0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[n+;H0:9](-[*:10]):[cH;+0:11]:1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1.[OH2;+0:20]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:20].[*:4]-[C;H0;+0:5]1=[CH;+0:11]-[N;H0;+0:9](-[*:10])-[CH;+0:8]=[CH;+0:7]-[CH2;+0:6]-1.[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa.Roychoudhury S, May TB, Gill JF, Singh SK, Feingold DS, Chakrabarty AM1989 Jun 52470755
Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa.Snook CF, Tipton PA, Beamer LJ2003 Apr 2912705829